Former pound for pound boxing world champ Holm (8-0) is coming off a split decision win in her UFC debut over Raquel Pennington. Six of her wins were by TKO or KO.
Reneau (6-1) has yet to be finished, having finished all but one of her wins. In her last fight, she defeated Jessica Andrade by triangle choke.
The winner would make a case for a possible title shot against champion Ronda Rousey.
The match will air on Fox Sports 1 July 15th.